Human plasma concentrations of trimethylamine <i>N</i>-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice-Reference-Cited by-同舟云学术

Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice

Published:2018 Issue:6 Volume:43 Page:387-393
ISSN:0388-1350
Container-title:The Journal of Toxicological Sciences
language:en
Short-container-title:J. Toxicol. Sci.

Author:

Shimizu Makiko¹,Suemizu Hiroshi²,Mizuno Sawa¹,Kusama Takashi¹,Miura Tomonori¹,Uehara Shotaro²,Yamazaki Hiroshi¹

Affiliation:

1. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

2. Central Institute for Experimental Animals

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Link

https://www.jstage.jst.go.jp/article/jts/43/6/43_387/_pdf

Reference27 articles.

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2. Bain, M.A., Fornasini, G. and Evans, A.M. (2005): Trimethylamine: metabolic, pharmacokinetic and safety aspects. Curr. Drug Metab., 6, 227-240.

3. Bain, M.A., Milne, R.W. and Evans, A.M. (2006): Disposition and metabolite kinetics of oral L-carnitine in humans. J. Clin. Pharmacol., 46, 1163-1170.

4. Bennett, B.J., de Aguiar Vallim, T.Q., Wang, Z., Shih, D.M., Meng, Y., Gregory, J., Allayee, H., Lee, R., Graham, M., Crooke, R., Edwards, P.A., Hazen, S.L. and Lusis, A.J. (2013): Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab., 17, 49-60.

5. Cashman, J.R., Lattard, V. and Lin, J. (2004): Effect of total parenteral nutrition and choline on hepatic flavin-containing and cytochrome P-450 monooxygenase activity in rats. Drug Metab. Dispos., 32, 222-229.

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