Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs
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Published:2016
Issue:1
Volume:41
Page:115-122
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ISSN:0388-1350
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Container-title:The Journal of Toxicological Sciences
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language:en
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Short-container-title:J. Toxicol. Sci.
Author:
Wada Takeshi12, Nakamura Yuji1, Cao Xin1, Ohara Hiroshi3, Izumi-Nakaseko Hiroko1, Ando Kentaro1, Nakazato Yuji4, Sugiyama Atsushi1
Affiliation:
1. Department of Pharmacology, Faculty of Medicine, Toho University 2. Department of Cardiology, Juntendo University School of Medicine 3. Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University, Faculty of Medicine 4. Department of Cardiology, Juntendo University School of Medicine, Urayasu Hospital Heart center
Publisher
Japanese Society of Toxicology
Reference20 articles.
1. Acosta, E.P. and Flexner, C. (2011): Antiviral agents (nonretroviral). In Goodman & Gilman’s the pharmacological basis of therapeutics. 12th ed. (Brunton, L.L., Chabner, B.A. and Knollmann, B.C., eds.), pp.1593-1622, McGraw-Hill, New York. 2. Braeunig, J.H., Schweda, F., Han, P.L. and Seifert, R. (2013): Similarly potent inhibition of adenylyl cyclase by p-site inhibitors in hearts from wild type and AC5 knockout mice. PLoS One, 8, e68009. 3. Ishizaka, T., Takahara, A., Iwasaki, H., Mitsumori, Y., Kise, H., Nakamura, Y. and Sugiyama, A. (2008): Comparison of electropharmacological effects of bepridil and sotalol in halothane-anesthetized dogs. Circ. J., 72, 1003-1011. 4. Iwatsubo, K., Bravo, C., Uechi, M., Baljinnyam, E., Nakamura, T., Umemura, M., Lai, L., Gao, S., Yan, L., Zhao, X., Park, M., Qiu, H., Okumura, S., Iwatsubo, M., Vatner, D.E., Vatner, S.F. and Ishikawa, Y. (2012): Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase. Am. J. Physiol. Heart Circ. Physiol., 302, H2622-H2628. 5. Iwatsubo, K., Minamisawa, S., Tsunematsu, T., Nakagome, M., Toya, Y., Tomlinson, J.E., Umemura, S., Scarborough, R.M., Levy, D.E. and Ishikawa, Y. (2004): Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration. J. Biol. Chem., 279, 40938-40945.
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