Pharmacokinetics of tacrolimus following an overdose in a patient with extreme obesity and genotype <i>CYP3A5*3/*3</i>: a case report

Author:

Hirai Toshinori1,Morikawa Yoshihiko1,Sasaki Noriko1,Kato Hideo1,Nakato Daisuke2,Hirayama Masahiro2,Kaneko Tadashi3,Imai Hiroshi3,Iwamoto Takuya1

Affiliation:

1. Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University

2. Department of Pediatrics, Mie University Hospital, Faculty of Medicine, Mie University

3. Emergency and Critical Care Center, Mie University Hospital, Faculty of Medicine, Mie University

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference20 articles.

1. Andrews, L.M., de Winter, B.C., Tang, J.T., Shuker, N., Bouamar, R., van Schaik, R.H., Koch, B.C., van Gelder, T. and Hesselink, D.A. (2017): Overweight Kidney Transplant Recipients Are at Risk of Being Overdosed Following Standard Bodyweight-Based Tacrolimus Starting Dose. Transplant. Direct, 3, e129.

2. Andrews, L.M., Hesselink, D.A., van Schaik, R.H., van Gelder, T., de Fijter, J.W., Lloberas, N., Elens, L., Moes, D.J. and de Winter, B.C. (2019): A population pharmacokinetic model to predict the individual starting dose of tacrolimus in adult renal transplant recipients. Br. J. Clin. Pharmacol., 85, 601-615.

3. Bonneville, E., Gautier-Veyret, E., Ihl, C., Hilleret, M.N., Baudrant, M., Fonrose, X. and Stanke-Labesque, F. (2020): Unexpected overdose blood concentration of tacrolimus: keep in mind the role of inflammation. Br. J. Clin. Pharmacol., 86, 1888-1891.

4. Brill, M.J., Diepstraten, J., van Rongen, A., van Kralingen, S., van den Anker, J.N. and Knibbe, C.A. (2012): Impact of obesity on drug metabolism and elimination in adults and children. Clin. Pharmacokinet., 51, 277-304.

5. Brunet, M., van Gelder, T., Åsberg, A., Haufroid, V., Hesselink, D.A., Langman, L., Lemaitre, F., Marquet, P., Seger, C., Shipkova, M., Vinks, A., Wallemacq, P., Wieland, E., Woillard, J.B., Barten, M.J., Budde, K., Colom, H., Dieterlen, M.T., Elens, L., Johnson-Davis, K.L., Kunicki, P.K., MacPhee, I., Masuda, S., Mathew, B.S., Millán, O., Mizuno, T., Moes, D.A., Monchaud, C., Noceti, O., Pawinski, T., Picard, N., van Schaik, R., Sommerer, C., Vethe, N.T., de Winter, B., Christians, U. and Bergan, S. (2019): Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report. Ther. Drug Monit., 41, 261-307.

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