Establishment of an <i>in vitro</i> cholestasis risk assessment system using two-dimensional cultured HepaRG cells and 12 bile acids
Author:
Affiliation:
1. Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/48/1/48_47/_pdf
Reference43 articles.
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2. Burbank, M.G., Sharanek, A., Burban, A., Mialanne, H., Aerts, H., Guguen-Guillouzo, C., Weaver, R.J. and Guillouzo, A. (2017): From the cover: mechanistic insights in cytotoxic and cholestatic potential of the endothelial receptor antagonists using HepaRG cells. Toxicol. Sci., 157, 451-464.
3. De Bruyn, T., Chatterjee, S., Fattah, S., Keemink, J., Nicolaï, J., Augustijns, P. and Annaert, P. (2013): Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity. Expert Opin. Drug Metab. Toxicol., 9, 589-616.
4. Deferm, N., De Vocht, T., Qi, B., Van Brantegem, P., Gijbels, E., Vinken, M., de Witte, P., Bouillon, T. and Annaert, P. (2019): Current insights in the complexities underlying drug-induced cholestasis. Crit. Rev. Toxicol., 49, 520-548.
5. Fattinger, K., Funk, C., Pantze, M., Weber, C., Reichen, J., Stieger, B. and Meier, P.J. (2001): The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. Clin. Pharmacol. Ther., 69, 223-231.
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