Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver
Author:
Affiliation:
1. Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/46/12/46_601/_pdf
Reference27 articles.
1. Arakawa, A., Otani, M., Iwashita, K. and Yamazaki, K. (2017): Molecular dynamics mechanism to generate species differences in inhibition of protoporphyrinogen oxidase by flumioxazin. Comput. Toxicol., 1, 12-21.
2. Buist, S.C. and Klaassen, C.D. (2004): Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels. Drug Metab. Dispos., 32, 620-625.
3. Dayan, F.E. and Duke, S.O. (2010): Protoporphyrinogen Oxidase-Inhibiting Herbicides. In: Hayes' Handbook of Pesticide Toxicology (Third Edition), Chpter 81, pp.1733-1751.
4. Eguchi, A., Fukunaga, S., Ogata, K., Kushida, M., Asano, H., Cohen, S.M. and Sukata, T. (2021): Chimeric mouse with humanized liver is an appropriate animal model to investigate mode of action for porphyria-mediated hepatocytotoxicity. Toxicol. Pathol., 49, 1243-1254.
5. European Food Safety Authority. (2015): Conclusion on the peer review of the pesticide risk assessment of the active substance pyraflufen-ethyl. EFSA J., 13, 4001.
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2. Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil;Regulatory Toxicology and Pharmacology;2022-12
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