Rat model for investigating ACTH-independent angiotensin-induced aldosterone secretion-Reference-Cited by-同舟云学术

Rat model for investigating ACTH-independent angiotensin-induced aldosterone secretion

Published:2000-03 Issue:1 Volume:1 Page:36-39
ISSN:1470-3203
Container-title:Journal of the Renin-Angiotensin-Aldosterone System
language:en
Short-container-title:J Renin Angiotensin Aldosterone Syst

Author:

Roesch Darren M¹,Ying Tian ²,Verbalis Joseph G²,Sandberg Kathryn²

Affiliation:

1. Divisions of Endocrinology and Metabolism and Nephrology and Hypertension and Department of Medicine, Georgetown University, Washington, DC, USA, roeschd@gunet. georgetown.edu

2. Divisions of Endocrinology and Metabolism and Nephrology and Hypertension and Department of Medicine, Georgetown University, Washington, DC, USA

Abstract

Study of the acute effects of angiotensin II (Ang II) on aldosterone secretion has been hindered by the confounding influence of Ang II-induced adrenocorticotropic hormone (ACTH) secretion on aldosterone secretion, and by the fact that when laboratory rats are fed standard laboratory chows that are high in sodium, the adrenal is only minimally responsive to Ang II. In this study, we report the development of a model of Ang II-induced aldosterone secretion in NaCl-deprived, dexamethasone (DEX)-treated rats. This model allows the observation of (a) a high magnitude of Ang II-induced aldosterone secretion, (b) a return of plasma aldosterone levels to baseline after stimulation, and (c) aldosterone secretion without the potentially confounding influence of ACTH stimulation.

Publisher

Hindawi Limited

Subject

Endocrinology,Internal Medicine

Link

http://journals.sagepub.com/doi/pdf/10.3317/jraas.2000.008

Reference27 articles.

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4. Plasma Aldosterone and Renin Activity Response to ACTH Infusion in Dexamethasone-Suppressed Normal and Sodium-Depleted Man

5. ATRIAL NATRIURETIC FACTOR INHIBITS THE STIMULATION OF ALDOSTERONE SECRETION BY ANGIOTENSIN II, ACTH AND POTASSIUMIN VITROAND ANGIOTENSIN II-INDUCED STEROIDOGENESISIN VIVO.

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