The Intestinal First-pass Metabolism of Substrates of CYP3A4 and P-glycoprotei—Quantitative Analysis Based on Information from the Literature

Author:

Kato Motohiro,Chiba Koji,Hisaka Akihiro,Ishigami Michi,Kayama Makoto,Mizuno Naomi,Nagata Yoshinori,Takakuwa Susumu,Tsukamoto Yuko,Ueda Kaoru,Kusuhara Hiroyuki,Ito Kiyomi,Sugiyama Yuichi

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference43 articles.

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2. Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism;Thummmel;Clin. Pharmacol. Ther.,1996

3. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine;Lampen;J. Pharmacol. Exp. Ther.,1998

4. The nifedipinerifampin interaction. Evidence for induction of gut wall metabolism;Holtbecker;Drug Metab. Dispos.,1996

5. Cellular localization of the multidrug resistance gene product in normal human tissues;Thiebaut;Proc. Natl. Acad. Sci. USA,1987

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