Hepatoprotective Effect of Seed Coat ofEuryale ferox Extract in Non-alcoholic Fatty Liver Disease Induced by High-fat Diet in Mice by Increasing IRs-1 and Inhibiting CYP2E1

Author:

Jian Tunyu1,Yu Chen2,Ding Xiaoqin1,Chen Jian13,Li Jiawei1,Zuo Yuanyuan1,Ren Bingru1,Lv Han1,Li Weilin14

Affiliation:

1. Institute of Botany, Jiangsu Province and Chinese Academy of Sciences

2. Department of Integrated TCM & Western Medicine, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University

3. Department of Food Science and Technology, College of Light Industry and Food Engineering, Nanjing Forestry University

4. College of Forestry, Nanjing Forestry University

Publisher

Japan Oil Chemists' Society

Subject

General Chemical Engineering,General Medicine,General Chemistry

Reference18 articles.

1. 7) Grasselli, E.; Voci, A.; Canesi, L.; De Matteis, R.; Goglia, F.; Cioffi, F.; Fugassa, E.; Gallo, G.; Vergani, L. Direct effects of iodothyronines on excess fat storage in rat hepatocytes. J. Hepatol. 54, 1230-1236 (2011).

2. 8) Day, C.P.; James, O.F. Steatohepatitis: a tale of two “hits”? Gastroenterology 114, 842-845 (1998).

3. 9) Zhang, F.; Hu, Z.; Li, G.; Huo, S.; Ma, F.; Cui, A.; Xue, Y.; Han, Y.; Gong, Q.; Gao, J. Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice. Hepatology 68, 1361-1375 (2018).

4. 10) Honma, M.; Sawada, S.; Ueno, Y.; Murakami, K.; Yamada, T.; Gao, J.; Kodama, S.; Izumi, T.; Takahashi, K.; Tsukita, S. Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers. Int. J. Obes. (Lond) 42, 1544-1555 (2018).

5. 11) Lee, G.H.; Oh, K.J.; Kim, H.R.; Han, H.S.; Lee, H.Y.; Park, K.G.; Nam, K.H.; Koo, S.H.; Chae, H.J. Effect of BI-1 on insulin resistance through regulation of CYP2E1. Sci. Rep. 6, 32229-32244 (2016).

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