NCCN Guidelines Insights: Primary Cutaneous Lymphomas, Version 2.2020

Author:

Mehta-Shah Neha1,Horwitz Steven M.2,Ansell Stephen3,Ai Weiyun Z.4,Barnes Jeffrey5,Barta Stefan K.6,Clemens Mark W.7,Dogan Ahmet2,Fisher Kristopher8,Goodman Aaron M.9,Goyal Gaurav10,Guitart Joan11,Halwani Ahmad12,Haverkos Bradley M.13,Hoppe Richard T.14,Jacobsen Eric15,Jagadeesh Deepa16,Lunning Matthew A.17,Mehta Amitkumar10,Olsen Elise A.18,Pro Barbara11,Rajguru Saurabh A.19,Shanbhag Satish20,Shaver Aaron21,Shustov Andrei22,Sokol Lubomir23,Torka Pallawi24,Torres-Cabala Carlos7,Wilcox Ryan25,William Basem M.26,Zain Jasmine27,Dwyer Mary A.28,Sundar Hema28,Kim Youn H.14

Affiliation:

1. 1Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

2. 2Memorial Sloan Kettering Cancer Center;

3. 3Mayo Clinic Cancer Center;

4. 4UCSF Helen Diller Family Comprehensive Cancer Center;

5. 5Massachusetts General Hospital Cancer Center;

6. 6Abramson Cancer Center at the University of Pennsylvania;

7. 7The University of Texas MD Anderson Cancer Center;

8. 8St. Jude Children's Research Hospital/The University of Tennessee Health Science Center;

9. 9UC San Diego Moores Cancer Center;

10. 10O'Neal Comprehensive Cancer Center at UAB;

11. 11Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

12. 12Huntsman Cancer Institute at the University of Utah;

13. 13University of Colorado Cancer Center;

14. 14Stanford Cancer Institute;

15. 15Dana-Farber/Brigham and Women's Cancer Center;

16. 16Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

17. 17Fred & Pamela Buffett Cancer Center;

18. 18Duke Cancer Institute;

19. 19University of Wisconsin Carbone Cancer Center;

20. 20The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

21. 21Vanderbilt-Ingram Cancer Center;

22. 22Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

23. 23Moffitt Cancer Center;

24. 24Roswell Park Comprehensive Cancer Center;

25. 25University of Michigan Rogel Cancer Center;

26. 26The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute;

27. 27City of Hope National Medical Center; and

28. 28National Comprehensive Cancer Network.

Abstract

Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma (CTCL), and Sézary syndrome (SS) is a rare erythrodermic and leukemic subtype of CTCL characterized by significant blood involvement. Although early-stage disease can be effectively treated predominantly with skin-directed therapies, systemic therapy is often necessary for the treatment of advanced-stage disease. Systemic therapy options have evolved in recent years with the approval of novel agents such as romidepsin, brentuximab vedotin, and mogamulizumab. These NCCN Guidelines Insights discuss the diagnosis and management of MF and SS (with a focus on systemic therapy).

Publisher

Harborside Press, LLC

Subject

Oncology

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