Author:
Greinix Hildegard T,Eikema Dirk-Jan,Koster Linda,Penack Olaf,Yakoub-Agha Ibrahim,Montoto Silvia,Chabannon Christian,Styczynski Jan,Nagler Arnon,Robin Marie,Robinson Stephen,Chalandon Yves,Mikulska Malgorzata,Schönland Stefan,Peric Zinaida,Ruggeri Annalisa,Lanza Francesco,De Wreede Liesbeth C,Mohty Mohamad,Basak Grzegorz W,Kröger Nicolaus
Abstract
Acute graft-versus-host disease (aGvHD) remains a major threat to successful outcome after allogeneic hematopoietic cell transplantation. Advances in prophylaxis and supportive care have taken place over the years. The aim of this study is to test whether incidence and mortality of aGvHD have been reduced over time.
102 557 patients with a median age of 47.6 years with malignancies after first allogeneic sibling or unrelated donor (URD) transplant were studied in the following periods: 1990-1995, 1996-2000, 2001-2005, 2006-2010, 2011-2015. Findings: 100-day-incidences of aGvHD grades II-IV decreased from 40%, to 38%, 32%, 29% and 28% over calendar time (p
Publisher
Ferrata Storti Foundation (Haematologica)
Cited by
35 articles.
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