Analysis of anamnestic and laboratory parameters in the study of the causes of latent insulin resistance

Abstract

Annotation. Insulin resistance (IR) is an urgent problem today. Regressive lifestyle modification, dietary habits, the tendency of the population to obesity, and a decrease in physical activity are additional factors in the development of IR. Given the relevance of this problem, the aim of this study was to investigate the influence of anamnestic data on laboratory indicators of IR in women of early reproductive age. A combined (retrospective + prospective) study was conducted on the basis of the D.K. Zabolotny Medical Professional College. The results of the study will be presented in 3 parts (articles). This study involved 82 women in the age range from 18 to 20 years, without complaints and concomitant diseases, 52 women were included in the main study group, 30 women were included in the control group. Anthropometric measurements were taken, information related to gestational age and birth weight, onset of menstrual function, regulation and main parameters of the menstrual cycle were recorded. Lifestyle, dietary habits, sleep, weight changes monitored over the past year, and physical activity were assessed. A family history was carefully collected, and in the presence of hereditary diseases, the maternal or paternal lineage was clarified. Laboratory parameters were collected. Insulin resistance was determined by the NOMA-IR index, Glucose Tolerance Test (GTT) + insulin determination, Matsuda Index, which gave the right to judge the latent insulin resistance in women of early reproductive age belonging to the main study group. Statistical calculations were made in Microsoft Excel Version: 16.0.13628.20214. As a result of the first part of the study, a small positive (direct) correlation was noted between the NOMA index and the following indicators: waist size (r = 0.353576), body mass index (BMI) (r = 0.36090423), TSH level increase (r = 0.212637559), total testosterone level (r = 0.241491459). There is also a slight inverse linear relationship between the NOMA index and the duration of menstrual regularity (r = -0.275476711), and a decrease in the duration of bleeding during menstruation (r = -0.263068287), and a decrease in DHEA-c levels (r = -0.239567359).