Dynamics of apatho-abolic manifestations in patients with negative symptoms in schizophrenia

Abstract

Annotation. Negative symptoms in schizophrenia are a significant prognostic factor of adverse consequences of schizophrenia. The question of the peculiarities of the manifestation of apatho-abulous manifestations in patients with negative symptoms in schizophrenia remains insufficiently studied. The purpose of the study was to study the peculiarities of the dynamics of the clinical-psychopathological structure and the severity of apatho-abolic manifestations in patients with negative symptoms in schizophrenia. 252 patients with negative symptoms of schizophrenia took part in the study: 83 patients with the first episode of schizophrenia, 88 patients with schizophrenia in a state of exacerbation, and 81 patients with schizophrenia in a state of remission. Clinical-psychopathological, psychometric (SANS scale) and statistical (Fisher's exact method and Fisher's angular transformation) research methods were used. As a result of the study, it was established that patients with the first episode of schizophrenia were characterized mainly by weak self-care disorders; a moderate decrease in productivity in work and study; a slight decrease in energy potential; subjective assessment of apatho-abulous disorders of a weak level. Patients with negative symptoms of schizophrenia in an acute state were characterized mainly by a moderate level of decrease in energy potential and violations in self-care; weak and moderate decrease in productivity in work and study; subjective assessment of apatho-abulous disorders as weak and moderate. Patients with negative symptoms of schizophrenia in a state of remission were characterized mainly by a pronounced and severe decrease in productivity in work and education; pronounced decrease in energy potential; weak, moderate and severe levels of violations in self-care; expressed subjective assessment of apatho-abolic disorders. Therefore, the dynamics of the development of apatho-abolic symptoms depending on the stage of the schizophrenic process are determined. The data kept in the study should be used in the diagnosis of patients with negative symptoms in schizophrenia, depending on the dynamics of the disease.