SEROTYPE-INDEPENDENT VACCINES AGAINST PNEUMOCOCCAL INFECTION-Reference-Cited by-同舟云学术

SEROTYPE-INDEPENDENT VACCINES AGAINST PNEUMOCOCCAL INFECTION

Published:2016-08-28 Issue:4 Volume: Page:76-85
ISSN:2686-7613
Container-title:Journal of microbiology, epidemiology and immunobiology
language:
Short-container-title:Zhurnal mikrobiologii, èpidemiologii i immunobiologii

Author:

Semenova I. B.¹,Mikhailova N. A.¹

Affiliation:

1. Mechnikov Research Institute of Vaccines and Sera

Abstract

Creation of serotype-independent vaccines includes 4 directions - construction of protein vaccines based on recombinant pneumococcus proteins, whole-cell killed or attenuated vaccines, DNA-vaccines and use of Streptococcus pneumoniae as a carrier for polysaccharide and conjugated vaccine preparations. Protein vaccines are the most widely studied. Around 20 proteins are described for pneumococcus - intracellular, associated with cell wall and secreted. The majority of researchers stop at construction of a vaccine preparation including a set of several proteins, protecting from colonization, invasion, pneumonia. Mechanism of action for protein vaccines differs from that of polysaccharide vaccines. Protein preparations create protection from several pneumococcus serotypes. Study of cross-activity of protein-candidates for vaccine preparations with human organism tissues is actual for preclinical studies. Selection of adjuvants is necessary for these vaccines, because aluminium hydroxide is not a suitable adjuvant for these preparations.

Publisher

Central Research Institute for Epidemiology

Subject

General Medicine

Reference50 articles.

1. Vorob'ev D.S., Semenova I.B. Pnevmokokkovyi poverkhnostnyi belok A i novye podkhody k razrabotke pnevmokokkovykh vaktsin. Zhurn. mikrobiol. 2011, 6: 107-113.

2. Vorob'ev D.S., Semenova I.B., Kurbatova E.A. Belki Streptococcus pneumoniae: perspektivy dlya sozdaniya vaktsiny protiv pnevmokokkovoi infektsii. Zhurn. mikrobiol. 2010, 6: 98-103.

3. Kostyukova N.N., Bekhalo V.A. Faktory patogennosti pnevmokokka i ikh protektivnye svoistva. Zhurn. mikrobiol. 2014, 3:67-77.

4. Kurbatova E.A., Vorob'ev D.S., Egorova N.B., Baturo A.P., Romanenko E.E., Markova M.E., Elkina S.I., Volokh Yu.V., Tsvetkov Yu.E., Sukhova E.V.,YashunskiiD.V.,Nifant'ev N.E., MikhailovaN.A. Shtammovye razlichiya vnutrividovoi immunogennoi aktivnosti antigennykh komponentov Streptococcus pneumoniae. Zhurn. mikrobiol. 2013, 5: 60-69.

5. Nisilevich V.F., Pugacheva N.L., Padyukov L.N., Gruber I.M., Reshilov L.N. Sravnitel'nyi analiz antigennykh preparatov iz nekapsul'nykh shtammov pnevmokokka. Zhurn. mikrobiol. 1987, 1: 8-12.

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