Affiliation:
1. University of California-San Diego, San Diego, California
Abstract
The small airways of the lungs are under constant assault from the pathogens and debris in the air that they must conduct to alveoli. Although hygiene is of paramount importance for respiratory health, the underlying principles of airway clearance have not been well integrated or established. Newly emerging concepts of simultaneous absorption and secretion of airway surface liquid (ASL) and the role of [Formula: see text] in the maturation of mucins have advanced from experimental evidence as well as observations from the congenital disease cystic fibrosis (CF) to present a novel model that integrates microanatomy with organ physiology to meet the constant challenge of cleaning small airways.
Funder
Cystic Fibrosis Research, Inc.
Cystic Fibrosis Foundation Therapeutics (Cystic Fibrosis Foundation Therapeutics, Inc.)
Nancy Olmsted Trust
Publisher
American Physiological Society
Cited by
24 articles.
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