Erythrocytes: Oxygen Sensors and Modulators of Vascular Tone-Reference-Cited by-同舟云学术

Erythrocytes: Oxygen Sensors and Modulators of Vascular Tone

Published:2009-04 Issue:2 Volume:24 Page:107-116
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Ellsworth Mary L.¹,Ellis Christopher G.²,Goldman Daniel²,Stephenson Alan H.¹,Dietrich Hans H.³,Sprague Randy S.¹

Affiliation:

1. Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri;

2. Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; and

3. Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri

Abstract

Through oxygen-dependent release of the vasodilator ATP, the mobile erythrocyte plays a fundamental role in matching microvascular oxygen supply with local tissue oxygen demand. Signal transduction within the erythrocyte and microvessels as well as feedback mechanisms controlling ATP release have been described. Our understanding of the impact of this novel control mechanism will rely on the integration of in vivo experiments and computational models.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00038.2008

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