Affiliation:
1. Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio
Abstract
Photoreceptor cells maintain a roughly constant length by continuously generating new outer segments from their base while simultaneously releasing mature outer segments engulfed by the retinal pigment epithelium (RPE). Thus postmitotic RPE cells phagocytose an immense amount of material over a lifetime, disposing of photoreceptor cell waste while retaining useful content. This review focuses on current knowledge of outer segment phagocytosis, discussing the steps involved along with their critical participants as well as how various perturbations in outer segment (OS) disposal can lead to retinopathies.
Publisher
American Physiological Society
Reference93 articles.
1. Disc Shedding in Rodlike and Conelike Photoreceptors of Tree Squirrels
2. Anderson DH, Fisher SK, Steinberg RH. Mammalian cones: disc shedding, phagocytosis, renewal.Invest Ophthalmol Vis Sci17: 117–133, 1978.
3. Photoreceptor Shedding Is Initiated by Light in the Frog Retina
4. Pharmacological and rAAV Gene Therapy Rescue of Visual Functions in a Blind Mouse Model of Leber Congenital Amaurosis
5. Besharse JC, Hollyfield JG. Turnover of mouse photoreceptor outer segments in constant light and darkness.Invest Ophthalmol Vis Sci18: 1019–1024, 1979.
Cited by
358 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献