Presenilins: Members of the γ-Secretase Quartets, But Part-Time Soloists Too-Reference-Cited by-同舟云学术

Presenilins: Members of the γ-Secretase Quartets, But Part-Time Soloists Too

Published:2008-08 Issue:4 Volume:23 Page:194-204
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Wakabayashi Tomoko¹²,De Strooper Bart¹²

Affiliation:

1. Department for Developmental and Molecular Genetics, VIB, Leuven, and

2. Center for Human Genetics, KULeuven, Leuven,

Abstract

The presenilins in combination with other proteins generate different γ-secretases, which are involved in the regulated intramembrane proteolysis of a variety of proteins. Understanding the specificity and regulation of these proteases will potentially lead to novel therapeutics for Alzheimer’s disease and cancer. Presenilins appear also to exert additional functions outside of the γ-secretase quartets, which needs further investigation.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00009.2008

Reference103 articles.

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2. Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate

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4. Regulated Intramembrane Proteolysis

5. The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

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