Transduction of Voltage and Ca2+ Signals by Slo1 BK Channels-Reference-Cited by-同舟云学术

Transduction of Voltage and Ca2+ Signals by Slo1 BK Channels

Published:2013-05 Issue:3 Volume:28 Page:172-189
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Hoshi T.¹,Pantazis A.²,Olcese R.²³⁴

Affiliation:

1. Department of Physiology, The University of Pennsylvania, Philadelphia, Pennsylvania;

2. Division of Molecular Medicine, Department of Anesthesiology, University of California, Los Angeles, California;

3. Brain Research Institute, University of California, Los Angeles, California; and

4. Cardiovascular Research Laboratories, University of California, Los Angeles, California

Abstract

Large-conductance Ca2+- and voltage-gated K+ channels are activated by an increase in intracellular Ca2+ concentration and/or depolarization. The channel activation mechanism is well described by an allosteric model encompassing the gate, voltage sensors, and Ca2+ sensors, and the model is an excellent framework to understand the influences of auxiliary β and γ subunits and regulatory factors such as Mg2+. Recent advances permit elucidation of structural correlates of the biophysical mechanism.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00055.2012

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