Noncytotoxic Roles of Granzymes in Health and Disease-Reference-Cited by-同舟云学术

Noncytotoxic Roles of Granzymes in Health and Disease

Published:2022-11-01 Issue:6 Volume:37 Page:323-348
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Richardson Katlyn C.¹²,Jung Karen¹²,Pardo Julian³⁴⁵,Turner Christopher T.⁶⁷^ORCID,Granville David J.¹²^ORCID

Affiliation:

1. International Collaboration on Repair Discoveries (ICORD), British Columbia Professional Firefighters’ Wound Healing Laboratory, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada

2. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

3. Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), Zaragoza, Spain

4. Department of Microbiology, Radiology, Pediatrics and Public Health, University of Zaragoza, Zaragoza, Spain

5. CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Zaragoza, Spain

6. Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia

7. Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia

Abstract

Granzymes are serine proteases previously believed to play exclusive and somewhat redundant roles in lymphocyte-mediated target cell death. However, recent studies have challenged this paradigm. Distinct substrate profiles and functions have since emerged for each granzyme while their dysregulated proteolytic activities have been linked to diverse pathologies.

Funder

Eczema Society of Canada

Gouvernement du Canada | Canadian Institutes of Health Research

LEO Fondet

Michael Smith Foundation for Health Research

Mitacs

Rick Hansen Institute

Cancer Research Society

Publisher

American Physiological Society

Subject

Physiology