Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients-Reference-Cited by-同舟云学术

Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients

Published:2022-01-01 Issue:1 Volume:37 Page:46-52
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Halpin-Veszeleiova Katarina¹,Hatfield Stephen M.¹^ORCID

Affiliation:

1. New England Inflammation and Tissue Protection Institute, Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts

Abstract

The hypoxia-hypoxia-inducible factor (HIF)-1α-A2-adenosinergic pathway protects tissues from inflammatory damage during antipathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygenation may contribute to the high mortality of oxygen-ventilated COVID-19 patients by exacerbating inflammatory lung damage. Restoration of this pathway with hypoxia-adenosinergic drugs may improve outcomes in these patients.

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiol.00010.2021

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