Heterodimers and Receptor Mosaics of Different Types of G-Protein-Coupled Receptors-Reference-Cited by-同舟云学术

Heterodimers and Receptor Mosaics of Different Types of G-Protein-Coupled Receptors

Published:2008-12 Issue:6 Volume:23 Page:322-332
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Fuxe Kjell¹,Marcellino Daniel¹,Guidolin Diego²,Woods Amina S.³,Agnati Luigi F.⁴

Affiliation:

1. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden;

2. Department of Anatomy and Physiology, University of Padua, Padua, Italy;

3. National Institute on Drug Abuse, NIH, DHHS, Baltimore, Maryland; and

4. Department of BioMedical Sciences, University of Modena, Modena, and IRCCS Lido, Venice, Italy

Abstract

Through an assembly of interacting GPCRs, heterodimers and high-order heteromers (termed receptor mosaics) are formed and lead to changes in the agonist recognition, signaling, and trafficking of participating receptors via allosteric mechanisms, sometimes involving the appearance of cooperativity. This field has now become a major research area, and this review deals with their physiology being integrators of receptor signaling in the CNS and their use as targets for novel drug development based on their unique pharmacology.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00028.2008

Reference102 articles.

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2. Cholecystokinin peptides in vitro modulate the characteristics of the striatal3H-N-propylnorapomorphine sites

3. Allosteric Modulation of Dopamine D2 Receptors by Homocysteine

4. Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons

5. Failure of neuropeptide Y in vitro to increase the number of α2-adrenergic binding sites in membranes of medulla oblongata of the spontaneous hypertensive rat*

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