Endocytic Receptors in the Renal Proximal Tubule-Reference-Cited by-同舟云学术

Endocytic Receptors in the Renal Proximal Tubule

Published:2012-08 Issue:4 Volume:27 Page:223-236
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Christensen Erik I.¹,Birn Henrik¹,Storm Tina¹,Weyer Kathrin¹,Nielsen Rikke¹

Affiliation:

1. Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark

Abstract

Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and cubilin. Recently, studies of patients with syndromes caused by dysfunctional receptors have supported the importance of these for protein clearance of human ultrafiltrate. This review focuses on the molecular biology and physiology of the receptors and their involvement in renal pathological conditions.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00022.2012

Reference191 articles.

1. How Does Proteinuria Cause Progressive Renal Damage?

2. Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability

3. Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1

4. Cubilin Is Essential for Albumin Reabsorption in the Renal Proximal Tubule

5. The binding sites for the very low density lipoprotein receptor and low-density lipoprotein receptor-related protein are shared within coagulation factor VIII

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