Membrane Microparticles: Two Sides of the Coin

Author:

Hugel Bénédicte1,Martínez M. Carmen1,Kunzelmann Corinne1,Freyssinet Jean-Marie1

Affiliation:

1. Institut d’Hématologie et d’Immunologie, Université Louis Pasteur, Faculté de Médecine, Strasbourg, France, and Unité 143 INSERM, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France

Abstract

Microparticles are plasma membrane-derived vesicles shed from stimulated cells, in the broad sense of the term. Their presence is interpreted by proximal or remote cells in fundamental physiological processes including intercellular communication, hemostasis, and immunity. On the other hand, variations of their number or characteristics are frequently observed in pathophysiological situations.

Publisher

American Physiological Society

Subject

Physiology

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