Rapid thalamocortical network switching mediated by cortical synchronization underlies propofol-induced EEG signatures: a biophysical model

Author:

Soplata Austin E.12ORCID,Adam Elie34ORCID,Brown Emery N.1345ORCID,Purdon Patrick L.1,McCarthy Michelle M.2,Kopell Nancy2ORCID

Affiliation:

1. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States

2. Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, United States

3. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States

4. Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States

5. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States

Abstract

GABAergic anesthetics induce alpha/low-beta and slow oscillations in the EEG, which interact in dose-dependent ways. We constructed a thalamocortical model to investigate how these interdependent oscillations change with propofol dose. We find two dynamic states of thalamocortical coordination, which change on the timescale of seconds and dose-dependently mirror known changes in EEG. Thalamocortical feedback determines the oscillatory coupling and power seen in each state, and this is primarily driven by cortical synchrony and brain stem neuromodulation.

Funder

HHS | NIH | National Institute of General Medical Sciences

John Simon Guggenheim Memorial Foundation

Massachusetts General Hospital

NSF | MPS | Division of Mathematical Sciences

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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