Electrophysiological markers of cochlear function correlate with hearing-in-noise performance among audiometrically normal subjects

Author:

Grant Kelsie J.1,Mepani Anita M.1,Wu Peizhe12,Hancock Kenneth E.12,de Gruttola Victor3,Liberman M. Charles124,Maison Stéphane F.124

Affiliation:

1. Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, Massachusetts

2. Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts

3. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts

4. Harvard Program in Speech and Hearing Bioscience and Technology, Harvard Medical School, Boston, Massachusetts

Abstract

Recent animal studies suggest that millions of people may be at risk of permanent impairment from cochlear synaptopathy, the age-related and noise-induced degeneration of neural connections in the inner ear that “hides” behind a normal audiogram. This study examines electrophysiological responses to clicks in a large cohort of subjects with normal hearing sensitivity. The resultant correlations with word recognition performance are consistent with an important contribution cochlear neural damage to deficits in hearing in noise abilities.

Funder

HHS | NIH | National Institute on Deafness and Other Communication Disorders

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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