Complementary yet divergent effects of exercise and an exercise mimetic on microbiome in high-fat diet-induced obesity-Reference-Cited by-同舟云学术

Complementary yet divergent effects of exercise and an exercise mimetic on microbiome in high-fat diet-induced obesity

Published:2024-02-01 Issue:2 Volume:56 Page:136-144
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Yu Josephine¹^ORCID,Youngson Neil A.¹^ORCID,Laybutt D. Ross²,Morris Margaret J.¹^ORCID,Leigh Sarah-Jane¹^ORCID

Affiliation:

1. School of Biomedical Sciences, UNSW Sydney, Sydney, New South Wales, Australia

2. Garvan Institute of Medical Research, St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia

Abstract

Exercise and NAD+ precursor supplementation exerted additive and independent effects on gut microbiota composition and inferred function in female mice with diet-induced obesity. Notably, combining exercise and oral nicotinamide mononucleotide supplementation restored inferred microbial functions to control levels, indicating that this combination may improve high-fat diet-induced alterations to microbial metabolism.

Funder

DHAC | National Health and Medical Research Council

Department of Education and Training | Australian Research Council

Rebecca L. Cooper Medical Research Foundation

Australian Government

Publisher

American Physiological Society

Subject

Genetics,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00066.2023

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