Gut microbiota and metabolomics profiles in patients with chronic stable angina and acute coronary syndrome-Reference-Cited by-同舟云学术

Gut microbiota and metabolomics profiles in patients with chronic stable angina and acute coronary syndrome

Published:2024-01-01 Issue:1 Volume:56 Page:48-64
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Ahmad Adilah F.¹²^ORCID,Caparrós-Martin Jose A.³,Gray Nicola⁴,Lodge Samantha⁴^ORCID,Wist Julien⁴^ORCID,Lee Silvia¹²⁵,O’Gara Fergal³⁶,Dwivedi Girish¹²⁷^ORCID,Ward Natalie C.⁸^ORCID

Affiliation:

1. Department of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia

2. Medical School, The University of Western Australia, Perth, Western Australia, Australia

3. Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, Western Australia, Australia

4. Australian National Phenome Centre and Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia

5. Department of Microbiology, PathWest Laboratory Medicine, Perth, Western Australia, Australia

6. BIOMERIT Research Centre, School of Microbiology, University College Cork, Cork, Ireland

7. Department of Cardiology, Fiona Stanley Hospital, Perth, Western Australia, Australia

8. Dobney Hypertension Centre, Medical School, The University of Western Australia, Perth, Western Australia, Australia

Abstract

The study found discriminative microorganisms differentiating patients with acute coronary syndrome (ACS) from healthy controls. In addition, reduced levels of certain bacterial metabolites and elevated sCD14 and sCD163 were observed in patients with ACS compared with healthy controls. Furthermore, modified small molecule metabolomic and lipidomic signatures were found in both patient groups. Although it is not known whether these differences in profiles are associated with disease development and/or progression, the findings provide exciting options for potential new disease-related mechanism(s) and associated therapeutic target(s).

Funder

Faculty of Health and Medical Sciences, University of Western Australia

Publisher

American Physiological Society

Subject

Genetics,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00072.2023

Reference84 articles.

1. Myocardial infarction and gut microbiota: An incidental connection

2. Medical management of chronic stable angina

3. 2022 ACC/AHA Key Data Elements and Definitions for Chest Pain and Acute Myocardial Infarction: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Data Standards

4. The effect of off-pump coronary artery bypass on mortality after acute coronary syndrome: A meta-analysis

5. Gut Microbiota, the Genome, and Diet in Atherogenesis