Synaptic inputs to motor neurons underlying muscle coactivation for functionally different tasks have different spectral characteristics

Author:

Borzelli Daniele12ORCID,Vieira Taian M. M.34ORCID,Botter Alberto34,Gazzoni Marco34ORCID,Lacquaniti Francesco25,d’Avella Andrea12ORCID

Affiliation:

1. Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy

2. Laboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, Italy

3. Laboratory for Engineering of the Neuromuscular System, Department of Electronics and Telecommunications, Politecnico di Torino, Turin, Italy

4. PoliToBIOMed Lab, Politecnico di Torino, Turin, Italy

5. Department of Systems Medicine and Center of Space BioMedicine, University of Rome Tor Vergata, Rome, Italy

Abstract

The characterization of the pathways underlying force generation or stiffness modulation are still unknown. In this study, we demonstrated that the common input to motor neurons of antagonist muscles shows a high-frequency component when muscles are coactivated to modulate stiffness but not to generate force. Our results provide novel insights on the neural strategies for the recruitment of multiple muscles by identifying specific spectral characteristics of the synaptic inputs underlying functionally different tasks.

Funder

EC | ERC | HORIZON EUROPE European Research Council

Ministero dell'Università e della Ricerca

Publisher

American Physiological Society

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