Inhibition of 5-HT alleviates PTSD-like behaviors and promotes hippocampal neuroplasticity by modulating hippocampal autophagy in rats-Reference-Cited by-同舟云学术

Inhibition of 5-HT alleviates PTSD-like behaviors and promotes hippocampal neuroplasticity by modulating hippocampal autophagy in rats

Published:2024-09-01 Issue:3 Volume:132 Page:979-990
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Bai Shi¹,Ying Zhong-Ming²,Ying Jia-Kang³^ORCID,Zhang Qin-Ying³,Lv Yu-Hang³,Wu Zhong-Min¹^ORCID

Affiliation:

1. Department of Anatomy, School of Medicine, Taizhou University, Jiaojiang, China

2. Department of Neurology, Taizhou Integrated Traditional Chinese and Western Medicine Hospital, Wenling, China

3. Department of Clinical Medicine, School of Medicine, Taizhou University, Jiaojiang, China

Abstract

The study demonstrated that sh-SERT exhibits significant anti-posttraumatic stress disorder (PTSD) effects, potentially mediated in part through the reduction of cellular autophagy to enhance hippocampal synaptic plasticity.

Funder

Zhejiang Provincial Science and Technology Department of Public Welfare Technology Application Project

Public Applied Technology Research Project of Zhejiang Province

Wenling Science and Technology Project

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00291.2024

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