Improving pregnancy outcomes in humans through studies in sheep

Author:

Morrison Janna L.1ORCID,Berry Mary J.2ORCID,Botting Kimberley J.3,Darby Jack R. T.1ORCID,Frasch Martin G.4ORCID,Gatford Kathryn L.5ORCID,Giussani Dino A.3,Gray Clint L.2,Harding Richard6,Herrera Emilio A.7,Kemp Matthew W.8,Lock Mitchell C.1ORCID,McMillen I. Caroline1,Moss Timothy J.9ORCID,Musk Gabrielle C.10ORCID,Oliver Mark H.11,Regnault Timothy R. H.12,Roberts Claire T.5ORCID,Soo Jia Yin1,Tellam Ross L.1ORCID

Affiliation:

1. Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia

2. Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand

3. Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom

4. Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington

5. Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia

6. Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia

7. Pathophysiology Program, Biomedical Sciences Institute (ICBM), Faculty of Medicine, University of Chile, Santiago, Chile

8. Division of Obstetrics and Gynecology, University of Western Australia, Perth, Western Australia, Australia

9. The Ritchie Centre, Hudson Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia

10. Animal Care Services, University of Western Australia, Perth, Western Australia, Australia

11. Liggins Institute, University of Auckland, Auckland, New Zealand

12. Department of Obstetrics and Gynecology and Department of Physiology and Pharmacology, Western University, and Children’s Health Research Institute, London, Ontario, Canada

Abstract

Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health and to provide an evidence base for translation of interventions to the clinic. The aim of this review is to highlight the advances in perinatal human medicine that have been achieved following translation of research using the pregnant sheep and fetus.

Funder

NHRMC

Australian Government Research Training Program

British Heart Foundation (BHF)

Wellcome Trust

Fondo Nacional de Desarrollo Científico y Tecnológico (National Fund for Scientific and Technological Development)

Department of Health, Australian Government | National Health and Medical Research Council (NHMRC)

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de recherche en santé du Canada)

Department of Industry, Innovation, Science, Research and Tertiary Education, Australian Government | Australian Research Council (ARC)

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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