The multidrug resistance protein 4 is expressed and functionally active in isolated bladder from pig-Reference-Cited by-同舟云学术

The multidrug resistance protein 4 is expressed and functionally active in isolated bladder from pig

Published:2024-09-01 Issue:3 Volume:327 Page:R291-R303
ISSN:0363-6119
Container-title:American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
language:en
Short-container-title:American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Author:

Gomes Erick de Toledo¹,Passos Gabriela Reolon¹,Antunes Natalícia de Jesus²,de Oliveira Mariana Gonçalves¹^ORCID,de Souza Valeria Barbosa¹,Schenka André Almeida¹,da Costa José Luiz²,Antunes Edson¹^ORCID,Mónica Fabiola Zakia¹^ORCID

Affiliation:

1. Section of Pharmacology, Department of Translational Medicine, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil

2. Campinas Poison Control Center, University of Campinas, Campinas, Brazil

Abstract

This study investigates the impact of pharmacological inhibition of MRP4 and MRP5 transporters on cyclic nucleotide signaling in isolated pig bladders. MK571 administration led to modest relaxation, with enhanced effects observed in the presence of phosphodiesterase inhibitors. However, substances elevating cAMP levels remained unaffected. MK571 selectively reduced extracellular cGMP levels. These findings shed light on the role of MRP4 transporters in the porcine bladder, opening avenues for further research into bladder disorders.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Cientifico e Tecnológico

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpregu.00238.2023

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