Oxidative stress induces release of mitochondrial DNA into the extracellular space in human placental villous trophoblast BeWo cells-Reference-Cited by-同舟云学术

Oxidative stress induces release of mitochondrial DNA into the extracellular space in human placental villous trophoblast BeWo cells

Published:2024-06-01 Issue:6 Volume:326 Page:C1776-C1788
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Gardner Jennifer J.¹,Cushen Spencer C.¹²^ORCID,Oliveira da Silva Reneé de Nazaré³,Bradshaw Jessica L.⁴^ORCID,Hula Nataliia³^ORCID,Gorham Isabelle K.⁵,Tucker Selina M.¹^ORCID,Zhou Zhengyang⁶,Cunningham Rebecca L.⁴^ORCID,Phillips Nicole R.⁵,Goulopoulou Styliani³^ORCID

Affiliation:

1. Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States

2. Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, Texas, United States

3. Lawrence D. Longo, MD Center for Perinatal Biology, Departments of Basic Sciences, Gynecology, and Obstetrics, Loma Linda University School of Medicine, Loma Linda, California, United States

4. Department of Pharmaceutical Sciences, System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas, United States

5. Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, United States

6. Department of Population & Community Health, University of North Texas Health Science Center, Fort Worth, Texas, United States

Abstract

This is the first study to test whether trophoblast cells release mitochondrial (mt)DNA in response to oxidative stress and to identify mechanisms of release and biological forms of mtDNA from this cellular type. This research identifies potential cellular mechanisms that can be used in future investigations to establish the source and biomarker potential of circulating mtDNA in preclinical experimental models and humans.

Funder

American Heart Association

HHS | National Institutes of Health

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00091.2024

Reference69 articles.

1. Hemochorial placentation: development, function, and adaptations†

2. Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways

3. The Role of Placental Nutrient Sensing in Maternal-Fetal Resource Allocation1

4. Growth and function of the normal human placenta

5. Mitochondrial DNA in innate immune responses and inflammatory pathology

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