Oscillators in the microvasculature: glycocalyx and beyond

Author:

Goligorsky Michael S.1ORCID

Affiliation:

1. Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College at the Touro University, Valhalla, New York

Abstract

The growing recognition of abundance of oscillating functions in biological systems has motivated this brief overview, which narrows down on the microvasculature. Specifically, it encompasses self-sustained oscillations of blood flow, hematocrit, and viscosity at bifurcations; blood flow effects on the oscillations of endothelial glycocalyx, mechanotransduction, and its termination to prime endothelial cells for the subsequent mechanical signaling event; oscillating affinity of hyaluronan-CD44 binding domain; spontaneous contractility of actomyosin complexes in the cortical actin web and its effects on the tension of the plasma membrane; reversible effects of sirtuin-1 on endothelial glycocalyx; and effects of plasma membrane tension on endo- and exocytosis. Some potential interactions between those oscillators, and their coupling, are discussed together with their transition into chaotic movements. Future in-depth understanding of the oscillatory activities in the microvasculature could serve as a guide to its chronotherapy under pathological conditions.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

New York Community Trust

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Role of blood flow in endothelial functionality: a review;Frontiers in Cell and Developmental Biology;2023-10-13

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