PTPMT1 protects cardiomyocytes from necroptosis induced by γ-ray irradiation through alleviating mitochondria injury-Reference-Cited by-同舟云学术

PTPMT1 protects cardiomyocytes from necroptosis induced by γ-ray irradiation through alleviating mitochondria injury

Published:2023-06-01 Issue:6 Volume:324 Page:C1320-C1331
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Yi Jing¹²,Yue Liang³,Zhang Yuning²⁴^ORCID,Tao Ning¹²,Duan Han²⁵,Lv Lin²,Tan Yingxia³^ORCID,Wang Hua¹²⁵^ORCID

Affiliation:

1. College of Life Science, Anhui Medical University, Hefei, People’s Republic of China

2. Department of Experimental Haematology, Beijing Institute of Radiation Medicine, Beijing, People’s Republic of China

3. Department of Stem Cell and Regenerative Medicine, Institute of Health Service and Transfusion Medicine, Beijing, People’s Republic of China

4. Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China

5. School of Life Sciences, Hebei University, Baoding, People’s Republic of China

Abstract

Effective strategies are still lacking for treating RIHD, with unclear pathological mechanisms. In cardiomyocytes model of radiation-induced injuries, we found γ-ray irradiation decreased the expression of PTPMT1, increased oxidative stress, and induced mitochondrial dysfunction and necroptosis in iPSC-CMs. ROS inhibition attenuated radiation-induced mitochondrial damage and necroptosis. PTPMT1 protected cardiomyocytes from necroptosis induced by γ-ray irradiation by alleviating mitochondrial injury. Therefore, PTPMT1 might be a potential strategy for treating RIHD.

Funder

Scientific Research Project, China

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00466.2022

Reference26 articles.

1. Radiation-Induced Cardiovascular Disease

2. Radiation-induced valvular heart disease

3. Effects of Adenovirus-Mediated Delivery of the Human Hepatocyte Growth Factor Gene in Experimental Radiation-Induced Heart Disease

4. Radiation-Induced Cardiovascular Disease

5. Necroptosis

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cardiovascular Toxicity in Cancer Therapy: Protecting the Heart while Combating Cancer;Current Cardiology Reports;2024-07-23

2. Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis;Ecotoxicology and Environmental Safety;2024-01