Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice-Reference-Cited by-同舟云学术

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Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice

Published:2024-04-01 Issue:4 Volume:326 Page:C1106-C1119
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Yu Huihui¹,Wang Xingxing¹,Tian Ruixian¹,Li Xuan¹,Xu Chenyi¹,Fei Jiajia¹²,Li Tengteng¹,Yin Zongzhi¹³^ORCID

Affiliation:

1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China

2. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China

3. NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, China

Abstract

Present work found that infection during pregnancy will increase myometrium contraction. Infection downregulated NHE1 and followed TREK1 expression and activation decrease in myometrium, resulting in increased myometrium contraction.

Funder

MOST | National Natural Science Foundation of China

Clinical medical research transformation project of anhui province

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00598.2023

Reference54 articles.

1. Normal flora and bacterial vaginosis in pregnancy: an overview

2. Genital Micro-Organisms in Pregnancy

3. Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth

4. Intrauterine Infection and Preterm Delivery

5. Epidemiology and causes of preterm birth

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