Ox-LDL-induced CD80<sup>+</sup> macrophages expand pro-atherosclerotic NKT cells via CD1d in atherosclerotic mice and hyperlipidemic patients-Reference-Cited by-同舟云学术

Ox-LDL-induced CD80⁺ macrophages expand pro-atherosclerotic NKT cells via CD1d in atherosclerotic mice and hyperlipidemic patients

Published:2024-06-01 Issue:6 Volume:326 Page:C1563-C1572
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Wang Yin¹²³^ORCID,Zou Yao⁴^ORCID,Jiang Qingsong¹²⁵,Li Wenming⁶,Chai Xinyu¹²³^ORCID,Zhao Tingrui⁷^ORCID,Liu Siyi¹²³,Yuan Zhiyi¹²³,Yu Chao¹²³^ORCID,Wang Tingting¹²³^ORCID

Affiliation:

1. College of Pharmacy, Chongqing Medical University, Chongqing, People’s Republic of China

2. Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing, People’s Republic of China

3. Chongqing Pharmacodynamic Evaluation Engineering Technology Research Center, Chongqing, People’s Republic of China

4. Department of Pharmacy, People’s Hospital of Chongqing Liangjiang New District, Chongqing, People’s Republic of China

5. Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing, People’s Republic of China

6. Department of Clinical Laboratory, University-Town Hospital of Chongqing Medical University, Chongqing, People’s Republic of China

7. Department of Clinical Pharmacy, The Third Hospital of Mianyang, Sichuan Mental Health Center, Sichuan, People’s Republic of China

Abstract

This work proposed the ox-LDL-CD80+ monocyte/macrophage-CD1d-NKT cell-IFN-γ axis in the progression of atherosclerosis. The proinflammatory IFN-γ+ NKT cells are closely related to CD1d+CD80+ monocytes in hyperlipidemic patients. Inhibiting CD80+ macrophages to present lipid antigens to NKT cells through CD1d blocking may be a new therapeutic target for atherosclerosis.

Funder

Chongqing Municipal Education Commission

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00043.2024

Reference39 articles.

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