A classic learning opportunity from Fenn, Rahn, and Otis (1946): the alveolar gas equation

Author:

Curran-Everett Douglas1

Affiliation:

1. Division of Biostatistics, National Jewish Medical and Research Center, and Departments of Preventive Medicine and Biometrics and of Physiology and Biophysics, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado

Abstract

The alveolar gas equation, the focus of a classic paper by Fenn, Rahn, and Otis, provides a framework for understanding the mechanisms involved in pulmonary gas exchange as well as the limits of human performance. The classic 1946 paper by Fehn, Rahn, and Otis gives your students an opportunity to learn about the alveolar gas equation from the physiologists who pioneered it and demonstrates that mathematics and data graphics are fundamental tools with which to learn respiratory physiology. In this essay, I outline avenues of discovery by which your students can explore the alveolar gas equation. Meaningful learning stems from inspiration: to learn, you must be inspired to learn. If anyone can inspire learning in respiratory physiology, it is Wallace Fenn, Hermann Rahn, and Arthur Otis.

Publisher

American Physiological Society

Subject

General Medicine,Physiology,Education

Reference15 articles.

1. Guidelines for reporting statistics in journals published by the American Physiological Society

2. Fenn WO, Rahn H, and Otis AB. A theoretical study of the composition of the alveolar air at altitude. Am J Physiol 146: 637–653, 1946. http://ajplegacy.physiology.org/cgi/reprint/146/5/637.

3. Hlastala MP and Berger AJ. Physiology of Respiration. New York: Oxford Univ. Press, 1996.

4. My Initiation into Respiratory Physiology

5. Otis AB and Rahn H. Development of concepts in Rochester, New York, in the 1940s. In: Pulmonary Gas Exchange, edited by West JB. New York: Academic, 1980, vol. 1, chapt. 2, p. 33–66.

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