Aryl hydrocarbon receptor activity in intestinal epithelial cells in the formation of colonic tertiary lymphoid tissues-Reference-Cited by-同舟云学术

Aryl hydrocarbon receptor activity in intestinal epithelial cells in the formation of colonic tertiary lymphoid tissues

Published:2024-08-01 Issue:2 Volume:327 Page:G154-G174
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Garcia-Villatoro E. L.¹,Ufondu A.²,Callaway E. S.²,Allred K. F.¹³^ORCID,Safe S. H.⁴,Chapkin R. S.¹⁵^ORCID,Jayaraman A.¹²,Allred C. D.¹³^ORCID

Affiliation:

1. Department of Nutrition, Texas A&M University, College Station, Texas, United States

2. Department of Chemical Engineering, Texas A&M University, College Station, Texas, United States

3. Department of Nutrition, University of North Carolina Greensboro, Greensboro, North Carolina, United States

4. Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas, United States

5. Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, Texas, United States

Abstract

This is the first research of its kind to demonstrate a clear connection between biological sex and the development of tertiary lymphoid tissues (TLT) in the colon. In addition, the research finds that in a preclinical model of inflammatory bowel disease, the expression of the aryl hydrocarbon receptor (AhR) influences the development of these structures in a sex-specific manner.

Funder

Cancer Prevention and Research Institute of Texas

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Environmental Health Sciences

Lake Simpson Endowed Chair

Allen Endowed Chair in Nutrition and Chronic Disease Prevention

Syd Kyle Endowed Chair

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00274.2023

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