Modeling pancreatic pathophysiology using genome editing of adult stem cell-derived and induced pluripotent stem cell (iPSC)-derived organoids-Reference-Cited by-同舟云学术

Modeling pancreatic pathophysiology using genome editing of adult stem cell-derived and induced pluripotent stem cell (iPSC)-derived organoids

Published:2021-06-01 Issue:6 Volume:320 Page:G1142-G1150
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Hirshorn Sabrina T.¹,Steele Nina²,Zavros Yana¹

Affiliation:

1. Department of Cellular and Molecular Medicine, University of Arizona College of Medicine, Tucson, Arizona

2. Department of Surgery, University of Michigan, Ann Arbor, Michigan

Abstract

The goal of this review is not only to provide highlights on the development of organoid technology but also to subsequently use this information to study the pathophysiology of those specific mutations in the formation of malignant pancreatic and gastric cancer.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00329.2020

Reference83 articles.

1. Organoid Models of Human and Mouse Ductal Pancreatic Cancer