Posttranscriptional regulation of thiamin transporter-1 expression by microRNA-200a-3p in pancreatic acinar cells-Reference-Cited by-同舟云学术

Posttranscriptional regulation of thiamin transporter-1 expression by microRNA-200a-3p in pancreatic acinar cells

Published:2020-09-01 Issue:3 Volume:319 Page:G323-G332
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Ramamoorthy Kalidas¹,Anandam Kasin Yadunandam¹²,Yasujima Tomoya³,Srinivasan Padmanabhan¹²,Said Hamid M.¹⁴²

Affiliation:

1. Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, California

2. Department of Medical Research, Veterans Affairs Medical Center, Long Beach, California

3. Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Japan

4. Department of Medicine, School of Medicine, University of California, Irvine, California

Abstract

The findings of this study show, for the first time, that the membrane transporter of vitamin B1, i.e., thiamin transporter-1 (THTR-1), is subject to regulation by microRNAs (specifically miR-200a-3p) in mouse and human primary pancreatic acinar cells (PACs). The results also show that this posttranscriptional regulation has functional consequences on the ability of PACs to take in the essential micronutrient thiamin.

Funder

NIH

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00178.2020

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