Mapping the geographical distribution of the mucosa-associated gut microbiome in GI-symptomatic children with autism spectrum disorder-Reference-Cited by-同舟云学术

Mapping the geographical distribution of the mucosa-associated gut microbiome in GI-symptomatic children with autism spectrum disorder

Published:2024-08-01 Issue:2 Volume:327 Page:G217-G234
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Reeves Kimberly D.¹²,Figuereo Yosauri F.³,Weis Victoria G.³^ORCID,Hsu Fang-Chi⁴,Engevik Melinda A.⁵⁶^ORCID,Krigsman Arthur⁷,Walker Stephen J.³^ORCID

Affiliation:

1. Center for Precision Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States

2. Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem North Carolina, United States

3. Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States

4. Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States

5. Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, United States

6. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, United States

7. Pediatric Gastroenterology Resources, Georgetown, Texas, United States

Abstract

Analysis in stool samples has shown gut microbiota alterations in children with autism spectrum disorder (ASD) compared with typically developing (TD) children. However, it is unclear which segment(s) of the gut exhibit alterations in microbiome composition. In this study, we examined microbiota composition along the gastrointestinal (GI) tract in the stomach, duodenum, ileum, right colon, and rectum. We found site-specific and sex-specific differences in the gut microbiota of children with ASD, compared with controls.

Funder

Brain Foundation Award

AGA Research Foundation (American Gastroenterological Association

HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00101.2024

Reference109 articles.

1. Role of Gut Microbiome in Autism Spectrum Disorder and Its Therapeutic Regulation

2. The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

3. Gut flora in health and disease

4. Direct Analysis of Genes Encoding 16S rRNA from Complex Communities Reveals Many Novel Molecular Species within the Human Gut