HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia-Reference-Cited by-同舟云学术

HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia

Published:2021-11-01 Issue:5 Volume:321 Page:G588-G602
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Stewart Amy Stieler¹^ORCID,Schaaf Cecilia Renee¹^ORCID,Luff Jennifer A.¹,Freund John M.¹,Becker Thomas C.²,Tufts Sara R.¹,Robertson James B.¹,Gonzalez Liara M.¹^ORCID

Affiliation:

1. College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina

2. Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina

Abstract

This paper supports that rISCs are resistant to ischemic injury and likely an important source of cellular renewal following near-complete epithelial loss. Furthermore, we have evidence that HOPX controls ISC activity state and may be a critical signaling pathway during ISC-mediated repair. Finally, we use multiple novel methods to evaluate ISCs in a translationally relevant large animal model of severe intestinal injury and provide evidence for the potential role of rISCs as therapeutic targets.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | NIH Office of the Director

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00165.2021

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