Affiliation:
1. Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
Abstract
It is well established that cancer arises in chronically inflamed tissue, and this is particularly notable in the gastrointestinal tract. Classic examples include Helicobacter pylori-associated gastric cancer, hepatocellular carcinoma, and inflammatory bowel disease-associated colorectal cancer. There is growing evidence to suggest that this association is not coincidental but may indeed be causal. In this review, we discuss the role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy and outline some of the possible mechanisms involved.
Publisher
American Physiological Society
Subject
Physiology (medical),Gastroenterology,Hepatology,Physiology
Reference30 articles.
1. A polymorphism of the interleukin-1 β gene influences survival in pancreatic cancer
2. Barbera-Guillem E, Nyhus JK, Wolford CC, Friece CR, and Sampsel JW. Vascular endothelial growth factor secretion by tumor-infiltrating macrophages essentially supports tumor angiogenesis, and IgG immune complexes potentiate the process. Cancer Res 62: 7042-7049, 2002.
3. The role of STATs in transcriptional control and their impact on cellular function
4. Cotran RS, Kumar V, and Collins T. Pathologic Basis of Disease. Philadelphia: Saunders, 1999.
5. Inflammatory Cells and Cancer
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