The oncogenic function of PLAGL2 is mediated via ASCL2 and IGF2 and a Wnt-independent mechanism in colorectal cancer-Reference-Cited by-同舟云学术

The oncogenic function of PLAGL2 is mediated via ASCL2 and IGF2 and a Wnt-independent mechanism in colorectal cancer

Published:2023-08-01 Issue:2 Volume:325 Page:G196-G211
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Fischer Anthony D.¹^ORCID,Veronese Paniagua Daniel A.²³,Swaminathan Shriya²,Kashima Hajime⁴,Rubin Deborah C.⁴^ORCID,Madison Blair B.⁴^ORCID

Affiliation:

1. Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, United States

2. Washington University School of Medicine, Saint Louis, Missouri, United States

3. Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, United States

4. Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States

Abstract

A Let-7 target called PLAGL2 drives oncogenic transformation via Wnt-independent pathways. This work illustrates the robust effects of this zinc finger transcription factor in colorectal cancer (CRC) cell lines and nontransformed intestinal epithelium, with effects mediated, in part, via the direct target genes ASCL2 and IGF2. This has implications for the role of PLAGL2 in activation of onco-fetal and onco-stem cell pathways, contributing to immature and highly proliferative phenotypes in CRC.

Funder

American Cancer Society

HHS | NIH | National Cancer Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00058.2022

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