High-energy pacing inhibits slow-wave dysrhythmias in the small intestine-Reference-Cited by-同舟云学术

High-energy pacing inhibits slow-wave dysrhythmias in the small intestine

Published:2024-06-01 Issue:6 Volume:326 Page:G676-G686
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Nagahawatte Nipuni D.¹^ORCID,Avci Recep¹^ORCID,Paskaranandavadivel Niranchan¹^ORCID,Cheng Leo K.¹²³^ORCID

Affiliation:

1. Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand

2. Department of Surgery, Vanderbilt University, Nashville, Tennessee, United States

3. Riddet Institute Centre of Research Excellence, Palmerston North, New Zealand

Abstract

Glucagon was infused in pigs to induce hyperglycemia and the resulting slow-wave response in the intact jejunum was defined in high resolution for the first time. Subsequently, with pacing, the glucagon-induced dysrhythmias were suppressed and spatially entrained for the first time with a success rate of 85%. The ability to suppress slow-wave dysrhythmias through pacing is promising in treating motility disorders that are associated with intestinal dysrhythmias.

Funder

Riddet Institute

Royal Society of New Zealand | Marsden Fund

University of Auckland

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00254.2023

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