Implicating the cholecystokinin B receptor in liver stem cell oncogenesis-Reference-Cited by-同舟云学术

Implicating the cholecystokinin B receptor in liver stem cell oncogenesis

Published:2024-03-01 Issue:3 Volume:326 Page:G291-G309
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Gay Martha D.¹^ORCID,Drda Jack C.¹^ORCID,Chen Wenqiang¹,Huang Yimeng²,Yassin Amal A.²,Duka Tetyana¹,Fang Hongbin³,Shivapurkar Narayan¹^ORCID,Smith Jill P.¹²^ORCID

Affiliation:

1. Department of Medicine, Georgetown University, Washington, District of Columbia, United States

2. Department of Oncology, Georgetown University, Washington, District of Columbia, United States

3. Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University, Washington, District of Columbia, United States

Abstract

This investigation identified a novel pathway involving the activation of hepatic stem cells and liver oncogenesis. Receptor blockade or genetic disruption of the cholecystokinin-B receptor (CCK-BR) signaling pathway decreased the activation and proliferation of hepatic stem cells after liver injury without eliminating the regenerative capacity of healthy hepatocytes.

Funder

American Physiological Society

GU | Lombardi Comprehensive Cancer Center, Georgetown University

Georgetown University

HHS | NIH | NCI | Basic Research Laboratory

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Defense

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00208.2023

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