Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism(s)-Reference-Cited by-同舟云学术

Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism(s)

Published:2021-01-01 Issue:1 Volume:320 Page:G108-G116
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Anandam Kasin Yadunandam¹²,Srinivasan Padmanabhan¹²,Yasujima Tomoya³,Al-Juburi Saleh¹,Said Hamid M.¹⁴²

Affiliation:

1. Departments of Physiology/Biophysics, School of Medicine, University of California, Irvine, California

2. Department of Medical Research, Veterans Affairs Medical Center, Long Beach, California

3. Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Japan

4. Department of Medicine, School of Medicine, University of California, Irvine, California

Abstract

Findings of the current study demonstrate, for the first time, that exposure of pancreatic acinar cells to proinflammatory cytokines (including hyper IL-6) cause significant inhibition in vitamin B1 (thiamin; a micronutrient that is essential for normal cellular energy metabolism) and that this effect is mediated at the level of transcription of the thiamin transporter genes SLC19A2 and SLC19A3.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00361.2020

Reference44 articles.

1. Thiamin

2. Thiamine Deficiency in Cultured Neuroblastoma Cells: Effect on Mitochondrial Function and Peripheral Benzodiazepine Receptors

3. Antioxidant Effect of Thiamine on Acutely Alcoholized Rats and Lack of Efficacy Using Thiamine or Glucose to Reduce Blood Alcohol Content

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells;American Journal of Physiology-Gastrointestinal and Liver Physiology;2023-10-01

2. Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small intestinal epithelia;Nature Communications;2022-11-12

3. Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease;Frontiers in Medicine;2022-10-04

4. Alzheimer's disease is associated with disruption in thiamin transport physiology: A potential role for neuroinflammation;Neurobiology of Disease;2022-09

5. EnterotoxigenicEscherichia coliheat-labile toxin drives enteropathic changes in small intestinal epithelia;2022-08-24