Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose

Author:

Kweon Soo-Mi1,Irimia-Dominguez Jose2,Kim Gayeoun1,Fueger Patrick T.23ORCID,Asahina Kinji4ORCID,Lai Keith K.56,Allende Daniela S.5ORCID,Lai Quincy R.1,Lou Chih-Hong7,Tsark Walter M.8,Yang Ju Dong91011,Ng Dominic S.12,Lee Ju-Seog13,Tso Patrick14,Huang Wendong153ORCID,Lai Keane K. Y.13ORCID

Affiliation:

1. Department of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California, United States

2. Department of Molecular and Cellular Endocrinology and Comprehensive Metabolic Phenotyping Core, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, California, United States

3. City of Hope Comprehensive Cancer Center, Duarte, California, United States

4. Central Research Laboratory, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Japan

5. Department of Pathology, Cleveland Clinic, Cleveland, Ohio, United States

6. Contra Costa Pathology Associates, Pleasant Hill, California, United States

7. Gene Editing and Viral Vector Core, Beckman Research Institute of City of Hope, Duarte, California, United States

8. Transgenic/Knockout Mouse Program, Center for Comparative Medicine, Beckman Research Institute of City of Hope, Duarte, California, United States

9. Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, United States

10. Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, California, United States

11. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States

12. Departments of Medicine, Physiology, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

13. Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

14. Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States

15. Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, California, United States

Abstract

We have developed and now report on the first functional global midnolin knockout mouse model. We found that global heterozygous midnolin knockout attenuated the severity of nonalcoholic fatty liver disease (NAFLD) in mice fed a Western-style diet, high in fat, cholesterol, and fructose, and this attenuation in disease was associated with significantly reduced levels of large lipid droplets, hepatic free cholesterol, and serum LDL, with significantly differential gene expression involved in cholesterol/lipid metabolism.

Funder

Michael Kahn, Charles C. Yoo, Karol Endres, and the Cheng, Kan, Kwok, Lai, and Wu families

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3