Circular RNA RRM2 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miR-142-5p to increase NRG1 expression-Reference-Cited by-同舟云学术

Circular RNA RRM2 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miR-142-5p to increase NRG1 expression

Published:2024-10-01 Issue:4 Volume:327 Page:G485-G498
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Wu Long-Fei¹²³,Zhou Zhi-Jiang¹,Zeng Yu-Heng¹,Yang Sheng-Li³,Zhang Qing-Ying¹^ORCID

Affiliation:

1. Department of Preventive Medicine, Shantou University Medical College, Shantou, People’s Republic of China

2. Department of Cardiology, People’s Hospital of Xinjin District, Chengdu, People’s Republic of China

3. First Affiliated Hospital of Shantou University Medical College, Shantou, People’s Republic of China

Abstract

CircRRM2 expression was downregulated in free fatty acid (FFA)-challenged hepatocytes and high-fat diet (HFD) fed mice. Overexpressed circular RNA ribonucleotide reductase subunit M2 (circRRM2) attenuated metabolic dysfunction-associated steatotic liver disease (MASLD) development by suppressing FFA-induced triglycerides accumulation. CircRRM2 targeted microRNA-142-5p (miR-142-5p), which served as an upstream inhibitor of neuregulin 1 (NRG1) and collaboratively regulated MASLD progression.

Funder

GDSTC | Natural Science Foundation of Guangdong Province

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00255.2023

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