Relationships among intragastric meal distribution during gastric emptying scintigraphy, water consumption during water load satiety testing, and symptoms of gastroparesis

Author:

Parkman Henry P.1ORCID,Wilson Laura A.2,Silver Paul1,Maurer Alan H.1ORCID,Sarosiek Irene3,Bulat Robert S.2,Kuo Braden4ORCID,Grover Madhusudan5ORCID,Farrugia Gianrico5ORCID,Chumpitazi Bruno P.6,Shulman Robert J.6,Malik Zubair1ORCID,Miriel Laura A.2,Tonascia James2,Hamilton Frank7,Abell Thomas L.8,Pasricha Pankaj J.2,McCallum Richard W.3,Koch Kenneth L.9,

Affiliation:

1. Gastroenterology Section, Temple University, Philadelphia, Pennsylvania, United States

2. Gastroenterology Section, Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States

3. Gastroenterology Section, Texas Tech University Health Sciences Center, El Paso, Texas, United States

4. Gastroenterology Section, Harvard Medical School, Boston, Massachusetts, United States

5. Gastroenterology Department, Mayo Clinic, Rochester, Minnesota, United States

6. Gastroenterology Section, Baylor College of Medicine, Children’s Nutrition Research Center, Houston, Texas, United States

7. Gastroenterology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, United States

8. Gastroenterology Section, University of Louisville, Louisville, Kentucky, United States

9. Section of Gastroenterology, Wake Forest University, Winston-Salem, North Carolina, United States

Abstract

IMD0 and WLST were assessed for their clinical utility in assessing patients with symptoms of gastroparesis. Low IMD0 is associated with less gastric retention and less heartburn. Volume of water consumed during WLST, while associated with IMD0, has associations with early satiety, postprandial fullness, loss of appetite, and nausea. IMD0 and WLST appear to overlap somewhat in their assessment of gastric physiology in adults with symptoms of gastroparesis but relate to different dyspeptic symptoms.

Funder

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

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